The Patel Lab in the Department of Orthopaedics at Emory University and the Atlanta VA Medical Center is focused on the repair and regeneration of musculoskeletal soft tissues. Specifically, we study and enhance cellular activity in these micro-environments, with the goal of taking novel biomaterial and therapeutic approaches from conceptualization to the clinic. We leverage principles of mechano-biology and cell-biomaterial interactions to guide macro-scale tissue engineering and functional outcomes in large animal models. By using engineering and biological principles, along with novel mechanical and imaging modalities, we strive to restore the structure, biology, and function of cartilage, meniscus, and musculoskeletal tissues.